mets affect on macrophage differentiation
| PAG Title | mets affect on macrophage differentiation |
| PAG ID | WAG000832 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Termil differentiation of cells is often accompanied by repression of cellular proliferation, suggesting that there is a mechanism by which these cellular functions are coordited. Macrophage differentiation is one model system in which this occurs; as macrophages differentiate, they also stop proliferating. Transcriptiol regulation plays a key role in cell cycle progression as well as many differentiation processes. Ras stimulates cell cycle progression in part through Ets transcription factors that bind to cell cycle regulatory genes to activate their expression. Ets transcription factors also help to induce early macrophage differentiation. The activation of Ras sigling by M-CSF activates transcription of genes involved in differentiation through the coordite expression of both Ets factors and AP-1. Other genes involved in cell cycle regulation involved the coordite action of E2F-1 and Ets transcription factors. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 674 |
| Information Content | Rich |
| Other IDs | |
| Base PAG ID | WAG000832 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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